The skin, including the hypodermis, is the largest body organ and is in constant contact with
the environment. Neurogenic inflammation is the result of the activity of nerve endings and …

Dysregulated mast cell-mediated inflammation and/or activation have been linked to a
number of human diseases, including asthma, anaphylaxis, chronic spontaneous urticaria …

Background Chronic prurigo (CPG) is characterized by intensive itch and interactions
among nerves, neuropeptides, and mast cells (MCs). The role of some neuropeptides such …

Background Osteoarthritis is increasingly recognized as the result of a complex interplay
between inflammation, chrondrodegeneration, and pain. Joint mast cells are considered to …

Mast cells (MCs) constitute an essential cell lineage that participates in innate and adaptive
immune responses and whose phenotype and function are influenced by tissue-specific …

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a common chronic pelvic disorder with
sensory symptoms of urinary urgency, frequency, and pain, indicating a key role for …

Mast cells are the major effectors in allergic reactions through degranulation and release of
inflammatory, vasoactive and nociceptive mediators associated with the pathogenesis of a …

Peripheral surgery can lead to a systemic aseptic inflammatory response comprising several
mediators aiming at restoring tissue homeostasis. It induces inflammatory mechanisms …

Despite the increasing use of protoplasts in plant biotechnology research, shoot
regeneration from protoplasts remains challenging. In this study, we investigated the factors …

Posttraumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary
headache developed within 7 days after head injury, and in a substantial number of patients …