[HTML][HTML] Schwann cell functions in peripheral nerve development and repair

M Bosch-Queralt, R Fledrich, RM Stassart - Neurobiology of disease, 2023 - Elsevier
The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease

Y Pu, X Fan, Z Zhang, Z Guo, Q Pan, W Gao… - Journal of Controlled …, 2023 - Elsevier
The inflammatory bowel disease (IBD) is incurable, chronic, recrudescent disorders in the
inflamed intestines. Current clinic treatments are challenged by systemic exposure-induced …

Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications

H Zhang, K Yang, F Chen, Q Liu, J Ni, W Cao… - Frontiers in …, 2022 - frontiersin.org
The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received
special attention because of its function in the development and progression of …

Neuroimmune interactions in the intestine

A Wallrapp, IM Chiu - Annual Review of Immunology, 2024 - annualreviews.org
Recent advances have contributed to a mechanistic understanding of neuroimmune
interactions in the intestine and revealed an essential role of this cross talk for gut …

Immune-epithelial cross talk in regeneration and repair

L Guenin-Mace, P Konieczny… - Annual review of …, 2023 - annualreviews.org
The epithelial tissues that line our body, such as the skin and gut, have remarkable
regenerative prowess and continually renew throughout our lifetimes. Owing to their barrier …

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

A Laddach, SH Chng, R Lasrado, F Progatzky… - Nature …, 2023 - nature.com
Glial cells have been proposed as a source of neural progenitors, but the mechanisms
underpinning the neurogenic potential of adult glia are not known. Using single cell …

Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells

P Wang, N Kljavin, TTT Nguyen, EE Storm, B Marsh… - Cell Stem Cell, 2023 - cell.com
The intestinal epithelium has high intrinsic turnover rate, and the precise renewal of the
epithelium is dependent on the microenvironment. The intestine is innervated by a dense …

[HTML][HTML] Tissue-specific immunity in helminth infections

F Vacca, G Le Gros - Mucosal immunology, 2022 - Elsevier
A characteristic feature of host responses to helminth infections is the development of
profound systemic and tissue-localised Type 2 immune responses that play critical roles in …

The role of cellular and molecular neuroimmune crosstalk in gut immunity

D Yang, N Almanzar, IM Chiu - Cellular & Molecular Immunology, 2023 - nature.com
The gastrointestinal tract is densely innervated by the peripheral nervous system and
populated by the immune system. These two systems critically coordinate the sensations of …

[HTML][HTML] The role of enteric glia in intestinal immunity

F Progatzky, V Pachnis - Current Opinion in Immunology, 2022 - Elsevier
Highlights•Enteric glial cells (EGCs) are required for maintenance of gut tissue
homeostasis.•GFAP+ EGCs regulate the health of the intestinal epithelial barrier.•EGCs …