The opioid crisis remains a major public health concern, causing significant morbidity and
mortality worldwide. Pain is frequently observed among individuals with opioid use disorder …

The rise of psychedelics in contemporary medicine has sparked interest in their potential
therapeutic applications. While traditionally associated with countercultural movements and …

The opioid and cannabinoid receptor systems are inextricably linked—overlapping at the
anatomical, functional and behavioural levels. Preclinical studies have reported that …

This is the first clinical practice guideline (CPG) from the American Academy of Pediatrics
outlining evidence-based approaches to safely prescribing opioids for acute pain in …

Importance Short-term and long-term opioid treatment have been associated with increased
pain sensitivity (ie, opioid-induced hyperalgesia). Treatment of opioid use disorder (OUD) …

Clinical recommendations continue to evolve as new consensus guidelines are published,
although institution-specific guidelines are most often followed. This review focuses on most …

Introduction Acute pain management is challenging in trauma patients undergoing
outpatient buprenorphine therapy at the time of injury due to the high binding affinity of this …

Pain and opioid use disorder (OUD) are inextricably linked, as the former can be a risk factor
for the development of the latter, and over a third of persons with OUD suffer concomitant …

Abstract Background and Aims People with opioid use disorder (OUD) commonly
experience pain including chronic pain. Despite the high prevalence, few studies have …

Introduction The administration of opioids can be followed by enduring neuroplastic
changes in the peripheral and central nervous systems. This remodeling can lead to opioid …