Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

The budding yeast Saccharomyces cerevisiae has been the principal organism used in
experiments to examine genetic recombination in eukaryotes. Studies over the past decade …

CRISPR/Cas9-based genome editing has revolutionized experimental molecular biology
and entered the clinical world for targeted gene therapy. Identifying DNA modifications …

Homologous recombination is a molecular process that has multiple important roles in DNA
metabolism, both for DNA repair and genetic variation in all forms of life. Generally …

The efficient repair of double-strand breaks (DSBs) in genomic DNA is important for the
survival of all organisms. In recent years, basic mechanisms of DSB repair in somatic plant …

L1 elements are ubiquitous human transposons that replicate via an RNA intermediate. We
have reconstituted the initial stages of L1 element transposition in vitro. The reaction …

The nature of the role played by mobile elements in host genome evolution is reassessed
considering numerous recent developments in many areas of biology. It is argued that easy …

A tremendous wealth of data is accumulating on the variety and distribution of transposable
elements (TEs) in natural populations. There is little doubt that TEs provide new genetic …

Long interspersed elements (LINE-1s) are abundant retrotransposons in mammalian
genomes that probably retrotranspose by target site-primed reverse transcription (TPRT) 1 …

It is commonly accepted that the reverse-transcribed cellular RNA molecules, called
retroposons, integrate at staggered breaks in mammalian chromosomes. However, unlike …