Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …

Essential tremor (ET) is one of the most common movement disorders, with a reported> 60
million affected individuals worldwide. The definition and underlying pathophysiology of ET …

Background Consensus criteria for classifying tremor disorders were published by the
International Parkinson and Movement Disorder Society in 1998. Subsequent advances with …

Massively parallel DNA-sequencing systems provide sequence of huge numbers of different
DNA strands at once. These technologies are revolutionizing our understanding in medical …

Essential tremor is one of the most common movement disorders. Despite its high
prevalence and heritability, the genetic aetiology of essential tremor remains elusive. Up to …

The neurodegenerative diseases are a diverse group of disorders characterized by
progressive loss of specific groups of neurons. These diseases affect different populations …

Essential tremor (ET) is the most common tremor disorder globally and is characterized by
kinetic tremor of the upper limbs, although other clinical features can also occur. Postmortem …

Mutations in the TAR DNA B inding P rotein gene (TARDBP), encoding the protein TDP‐43,
were identified in amyotrophic lateral sclerosis (ALS) patients. Interestingly, TDP‐43 positive …

Essential tremor is one of the most frequent movement disorders of humans and can be
associated with substantial disability. Some but not all persons with essential tremor develop …