Neutrophils play a key role in defence against infection and in the activation and regulation
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …

High serum lactate dehydrogenase (LDH) levels are typically associated with a poor
prognosis in many cancer types. Even the most effective drugs, which have radically …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Melanoma is one of the most immunologic malignancies based on its higher prevalence in
immune‐compromised patients, the evidence of brisk lymphocytic infiltrates in both primary …

Background Inflammatory mediators, including acute phase reactants and cytokines, have
been reported to be associated with clinical efficacy in patients with melanoma and other …

PURPOSE Currently, there are no robust biomarkers that predict immunotherapy outcomes
in metastatic melanoma. We sought to build multivariable predictive models for response …

In the last few years, immunotherapy has transformed the way we treat solid tumors,
including melanoma, lung, head neck, breast, renal, and bladder cancers. Durable …

Over the past decade, immune checkpoint blockade (ICB) therapy has revolutionized the
outlook for oncology with significant and sustained improvement in the overall patient …

Background An elevated neutrophil‐to‐lymphocyte ratio (NLR) is associated with poor
survival in patients with cancer, including those who receive immunotherapies. The authors …

Background Currently, there are no recognized or validated biomarkers to identify
hepatocellular carcinoma patients (HCC) likely to benefit from anti–PD‐1 therapy. We …