Eosinophils are evolutionarily conserved, pleotropic cells that display key effector functions
in allergic diseases, such as asthma. Nonetheless, eosinophils infiltrate multiple tumours …

Over the last decade, the emergence of several novel therapeutic approaches has changed
the therapeutic perspective of human malignancies. Adoptive immunotherapy through …

The guideline group was selected to be representative of UK-based medical experts with an
interest in myeloproliferative neoplasms and eosinophilia. PubMed and EMBASE were …

Multiparameter flow cytometry (MFC) is one of the essential ancillary methods in bone
marrow (BM) investigation of patients with cytopenia and suspected myelodysplastic …

Eosinophils are rare blood-circulating and tissue-infiltrating immune cells studied for
decades in the context of allergic diseases and parasitic infections. Eosinophils can secrete …

Purpose Biological therapies are gaining relevance in the management of CRSwNP with
few adverse events reported. Among these, dupilumab, an anti-IL4-Ra monoclonal antibody …

Background The peripheral blood eosinophil count prior to treatment has potential as a
predictive biomarker for a beneficial clinical response to cancer immunotherapies …

Background White cell count (WCC) is a clinical marker of inflammation. Data are limited
regarding the association of total and differential WCC with risk of mortality, and its role …

Endogenous cell autofluorescence is a common nuisance that complicates the use of
fluorescence microscopy. When using fluorescence-labeled antibodies for specific cell …

Abstract Background The KMT2A gene encoded lysine methyltransferase plays an essential
role in regulating gene expression during early development and hematopoiesis. To date …