High‐throughput metabolomics by 1D NMR

A Vignoli, V Ghini, G Meoni, C Licari… - Angewandte Chemie …, 2019 - Wiley Online Library
Metabolomics deals with the whole ensemble of metabolites (the metabolome). As one of
the‐omic sciences, it relates to biology, physiology, pathology and medicine; but metabolites …

From correlation to causation: analysis of metabolomics data using systems biology approaches

A Rosato, L Tenori, M Cascante, PR De Atauri Carulla… - Metabolomics, 2018 - Springer
Introduction Metabolomics is a well-established tool in systems biology, especially in the top–
down approach. Metabolomics experiments often results in discovery studies that provide …

Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19

T Matsuyama, SK Yoshinaga, K Shibue… - Cell Death & …, 2021 - nature.com
SARS-CoV-2 vaccinations have greatly reduced COVID-19 cases, but we must continue to
develop our understanding of the nature of the disease and its effects on human immunity …

[HTML][HTML] Uniqueness of the NMR approach to metabolomics

PG Takis, V Ghini, L Tenori, P Turano… - TrAC Trends in Analytical …, 2019 - Elsevier
NMR measures a relatively small portion of the human metabolome, which roughly
corresponds to all free small molecules present in concentrations≥ 1 μM. However, the …

Sex as an important factor in nanomedicine

MJ Hajipour, H Aghaverdi, V Serpooshan… - Nature …, 2021 - nature.com
Nanomedicine has demonstrated substantial potential to improve the quality and efficacy of
healthcare systems. Although the promise of nanomedicine to transform conventional …

Ambient PM2. 5 species and ultrafine particle exposure and their differential metabolomic signatures

FL Nassan, C Wang, RS Kelly, JA Lasky-Su… - Environment …, 2021 - Elsevier
Background The metabolomic signatures of short-and long-term exposure to PM 2.5 have
been reported and linked to inflammation and oxidative stress. However, little is known …

[HTML][HTML] A validated multi-matrix platform for metabolomic fingerprinting of human urine, feces and plasma using ultra-high performance liquid-chromatography …

E De Paepe, L Van Meulebroek, C Rombouts… - Analytica chimica …, 2018 - Elsevier
In recent years, metabolomics has surfaced as an innovative research strategy in human
metabolism, whereby selection of the biological matrix and its inherent metabolome is of …

Untargeted urinary metabolomics for bladder cancer biomarker screening with ultrahigh-resolution mass spectrometry

J Nizioł, K Ossoliński, A Płaza-Altamer, A Kołodziej… - Scientific Reports, 2023 - nature.com
Bladder cancer (BC) is a common urological malignancy with a high probability of death and
recurrence. Cystoscopy is used as a routine examination for diagnosis and following patient …

Age, sex, body mass index, diet and menopause related metabolites in a large homogeneous alpine cohort

V Verri Hernandes, N Dordevic, EM Hantikainen… - Metabolites, 2022 - mdpi.com
Metabolomics in human serum samples provide a snapshot of the current metabolic state of
an individuum. Metabolite concentrations are influenced by both genetic and environmental …

Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson's disease patients

G Meoni, L Tenori, S Schade, C Licari… - npj Parkinson's …, 2022 - nature.com
Parkinson's disease (PD) is the neurological disorder showing the greatest rise in
prevalence from 1990 to 2016. Despite clinical definition criteria and a tremendous effort to …