Microenvironment plays a crucial role in tumor development and progression. Cancer cells
modulate the tumor microenvironment, which also contribute to resistance to therapy …

Emmprin (basigin, CD147) is a cell surface glycoprotein that belongs to the immunoglobulin
superfamily. It is highly expressed on the surface of tumor cells and stimulates adjacent …

Matrix metalloproteinases (MMPs) comprise a family of 23 zinc-dependent enzymes
involved in various pathologic and physiologic processes. In cancer, MMPs contribute to …

Comprehending the pathogenesis of giant cell tumor of bone (GCT) is of critical importance
for developing novel targeted treatments for this locally-aggressive primary bone tumor. GCT …

Giant cell tumor of bone (GCTB)–related clonal aberrations occur in a background of
epigenetic histone modifications (especially the G34W mutation of H3F3A gene) that induce …

Breast cancer shows a strong predilection to metastasize to bone. Cell surface glycoprotein
extracellular matrix metalloproteinase inducer (EMMPRIN)/CD147 induces …

With the development of modern biomedicine, research on the molecular mechanism of
tumors has developed gradually. The CD147 gene has been applied to tumor molecular …

Although human mesenchymal stem cells (hMSCs) are a powerful tool for cell therapy,
prolonged culture times result in replicative senescence or acquisition of tumorigenic …

The effect of resveratrol on macrophage EMMPRIN expression and its potential mechanism
was investigated. Both EMMPRIN expression and MMP-9 activity, respectively assayed by …

Differentiation of committed precursor cells into the osteoblast lineage is tightly regulated by
several factors, including Runx2 and BMP2. We previously reported that C terminus of …