Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

BACKGROUND & AIMS: Tumor cells survive hypoxic conditions by inducing autophagy. We
investigated the roles of microRNAs (miRNAs) in regulating autophagy of hepatocellular …

Autophagy is activated in cancer cells during chemotherapy and often contributes to tumor
chemotherapy resistance. In this study, we characterized the role of microRNA-30a (miR …

(-)-Epigallocatechin-3-O-gallate (EGCG), the highest catechins from green tea, has
promisingly been found to sensitize the efficacy of several chemotherapy agents like …

Drug resistance elicited by cancer cells still constitutes a huge problem that frequently
impairs the efficacy of both conventional and novel molecular therapies. Chemotherapy …

Mechanistic details for the roles of sphingolipids and their downstream targets in the
regulation of tumor growth, response to chemo/radiotherapy, and metastasis have been …

Overexpression of oncomiR-21 has been observed in most cancer types, such as leukemia.
This miR has been implicated in a number of cellular processes, including chemoresistance …

Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancer, the third leading
cause of cancer-associated death worldwide. With the increasing prevalence of metabolic …