Corneal stromal wound healing is a complex event that occurs to restore the transparency of
an injured cornea. It involves immediate apoptosis of keratocytes followed by their activation …

Abstract The TGF beta-1,-2 and-3 isoforms are transcribed from different genes but bind to
the same receptors and signal through the same canonical and non-canonical signal …

The therapeutic effects of secreted factors (secretome) produced by bone marrow-derived
human mesenchymal stem cells (MSCs) were evaluated as a function of their growth in 2D …

Myofibroblasts are alpha-smooth muscle actin (SMA)+ cells that have a critical role in the
corneal stromal response to infections, injuries, and surgeries, and which produce corneal …

Severe corneal injuries often result in permanent vision loss and remain a clinical challenge.
Human bone marrow-derived mesenchymal stem cells (MSCs) and their secreted factors …

Adipose-derived stem cells are a subtype of mesenchymal stem cell that offers the important
advantage of being easily obtained (in an autologous manner) from low invasive …

Purpose This phase 1 study seeks to preliminarily evaluate the safety and efficacy of
decellularized human corneal stromal lamina transplantation with or without autologous …

Mesenchymal stem cells (MSCs) have unique and beneficial properties and are currently
used to treat a broad variety of diseases. These properties include the potential for …

Purpose: The aim of this phase 1 study was to preliminarily evaluate the safety and efficacy
of autologous adipose-derived adult stem cell (ADASC) implantation within the corneal …

Hepatocyte growth factor (HGF) is a glycoprotein produced by mesenchymal cells and
operates as a key molecule for tissue generation and renewal. During corneal injury, HGF is …