Inhibiting cell survival and inducing cell death are the main approaches of tumor therapy.
Autophagy plays an important role on intracellular metabolic homeostasis by eliminating …

Autophagy as a means of cell killing was first advanced by Clark's phenotypic description of
'Type II autophagic cell death'in 1990. However, this phenomenon later came into question …

The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain
containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns …

ATG4B stimulates autophagy by promoting autophagosome formation through reversible
modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase …

Proper regulation of mitophagy for mitochondrial homeostasis is important in various
inflammatory diseases. However, the precise mechanisms by which mitophagy is activated …

Both inflammasomes and autophagy have important roles in the intracellular homeostasis,
inflammation, and pathology; the dysregulation of these processes is often associated with …

Summary Elevated interleukin (IL)-1β levels, NLRP3 inflammasome activity, and systemic
inflammation are hallmarks of chronic metabolic inflammatory syndromes, but the …

Autophagy is one of the innate immune defense mechanisms against microbial challenges.
Previous in vitro and in vivo models of sepsis demonstrated that autophagy was activated …

The inflammasome is a large intracellular protein complex that activates inflammatory
caspase-1 and induces the maturation of interleukin (IL)-1β and IL-18. Mitophagy plays an …

The mitochondrion is also a major site for maintaining redox homeostasis between reactive
oxygen species (ROS) generation and scavenging. The quantity, quality, and functional …