Excess body weight is a global health problem due to sedentary lifestyle and unhealthy diet,
affecting 2 billion population worldwide. Obesity is a major risk factor for metabolic diseases …

As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

Background & Aims Adipose tissue dysfunction is involved in the development of insulin
resistance and is responsible for excessive lipid delivery to other organs such as the liver …

Understanding the consequences of individual transcriptome variation is fundamental to
deciphering human biology and disease. We implement a statistical framework to quantify …

Common metabolic diseases such as obesity, type 2 diabetes mellitus, and nonalcoholic
fatty liver disease significantly contribute to morbidity and mortality worldwide. They are …

Lipidomics is of growing importance for clinical and biomedical research due to many
associations between lipid metabolism and diseases. The discovery of these associations is …

This study used untargeted proteomics to compare blood proteomic profiles in two groups of
adults that differed widely in lifestyle habits. A total of 52 subjects in the lifestyle group …

Aims Heart failure with preserved ejection fraction (HFpEF) is a condition that commonly
coexists with type 2 diabetes mellitus (T2DM) and obesity. Whether the obesity-related …

Type 2 diabetes (T2D) is a common chronic disease whose etiology is known to have a
strong genetic component. Standard genetic approaches, although allowing for the …

Obesity is a current global challenge affecting all ages and is characterized by the up-
regulated secretion of bioactive factors/pathways which result in adipose tissue inflammation …