Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …

Tetramer formation of p53 is essential for its tumor suppressor function. p53 not only acts as
a tumor suppressor protein by inducing cell cycle arrest and apoptosis in response to …

Early in vivo studies demonstrated the involvement of a tumor-suppressing transcription
factor, p53, into cellular droplets such as Cajal and promyelocytic leukemia protein bodies …

Atomic resolution characterization of the full-length p53 tetramer has been hampered by its
size and the presence of extensive intrinsically disordered regions at both the N and C …

The small heat shock protein αB-crystallin is an oligomeric molecular chaperone that binds
aggregation-prone proteins. As a component of the proteostasis system, it is associated with …

The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene
transcription to regulate cell survival and proliferation. Dynamic control of p53 degradation …

The protein p53 is the main human tumor suppressor. Since its discovery, extensive
research has been conducted, which led to the general assumption that the purview of p53 …

The tumor suppressor p53 presents a great challenge for 3D structural analysis due to its
inherent flexibility. In this work, we gained insight into the structure of full‐length wild‐type …

Interactions between DNA and DNA-binding proteins play an important role in many
essential cellular processes. A key function of the DNA-binding protein p53 is to search for …

Sequence-specific DNA-binding proteins can maintain and regulate cellular functions by
accurately and quickly binding to target sequences among large amounts of nontarget DNA …