Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …

Oxidative stress is defined as the imbalance between reactive oxygen species (ROS)
production and the endogenous antioxidant defense system, leading to cellular damage …

G-quadruplex is a non-canonical nucleic acid structure formed by the folding of guanine rich
DNA or RNA. The conformation and function of G-quadruplex are determined by a number …

Living in an oxygen atmosphere demands an ability to thrive in the presence of reactive
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative …

The excessive production of reactive oxygen species (ROS) can lead to single nucleic acid
base damage, DNA strand breakage, inter-and intra-strand cross-linking of nucleic acids …

Abstract G-Quadruplexes (G4s) are widely studied secondary DNA/RNA structures, naturally
occurring when G-rich sequences are present. The strategic localization of G4s in genome …

G-Quadruplexes are non-B form DNA structures present at regulatory regions in the
genome, such as promoters of proto-oncogenes and telomeres. The prominence in such …

DNA G-quadruplexes (G4s) are known to be an integral part of the complex regulatory
systems in both normal and pathological cells. At the same time, the ability of G4s to impede …

Oxo-7, 8-dihydro-2′-deoxyguanosine (OG), one of the most common oxidative DNA
damages, causes genome instability and is associated with cancer, neurological diseases …

Telomeres are protective nucleoprotein structures that cap linear chromosome ends and
safeguard genome stability. Progressive telomere shortening at each somatic cell division …