Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Abstract The Diels–Alder reaction is one of the most powerful and widely used methods in
synthetic chemistry for the stereospecific construction of carbon–carbon bonds. Despite the …

Pericyclic reactions—which proceed in a concerted fashion through a cyclic transition state—
are among the most powerful synthetic transformations used to make multiple regioselective …

Covering: up to 2017 Cytochalasans are a class of natural products possessing a wide
range of important biological activities, yet the full biosynthetic steps towards the formation of …

Diels–Alder reactions are among the most powerful synthetic transformations to construct
complex natural products. Despite that increasing of enzymatic intramolecular Diels–Alder …

Abstract Natural Diels–Alderases that selectively form endo or exo products are increasingly
well known but generally form one stereoisomer with limited substrate scope. Here we report …

The pericyclases are a growing superfamily of enzymes that catalyze pericyclic reactions.
We report a pericyclase IccD catalyzing an inverse-electron demand Diels–Alder (IEDDA) …

Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide
synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed …

In 1990 the first fungal secondary metabolite biosynthetic gene was cloned in Aspergillus
nidulans. Thirty years later,> 30 biosynthetic gene clusters (BGCs) have been linked to …