Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons
and control the synthesis, release and uptake of dopamine. These G i/o-coupled inhibitory …

In this review we will critically assess the hypothesis that the reinforcing effect of virtually all
drugs of abuse is primarily dependent on activation of the mesolimbic dopamine system …

Behavioral Genetics, Fifth Edition provides an engaging and clear overview of human and
animal behavioral genetics that is designed to introduce students in the behavioral …

Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …

Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative
feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 …

Midbrain dopamine neurons are an essential component of the basal ganglia circuitry,
playing key roles in the control of fine movement and reward. Recently, it has been …

Drug addiction: bad habits add up | Nature Skip to main content Thank you for visiting nature.com.
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Drug dependence is a chronic, relapsing disorder in which compulsive drug-seeking and
drug-taking behaviours persist despite serious negative consequences. Addictive …

Understanding the molecular basis of addiction could be greatly aided by using forward
genetic manipulation to lengthen the list of candidate genes involved in this complex …

Fueled by anatomical, electrophysiological, and pharmacological analyses of endogenous
brain reward systems, norepinephrine (NE) was identified as a key mediator of both natural …