Defensins represent an evolutionary ancient family of antimicrobial peptides that play
diverse roles in human health and disease. Defensins are cationic cysteine-containing …

Cutaneous wound healing is a vital biological process that aids skin regeneration upon
injury. Wound healing failure results from persistent inflammatory conditions observed in …

Antimicrobial peptides and proteins (AMPs) are widespread in the living kingdom. They are
key effectors of defense reactions and mediators of competitions between organisms. They …

Fcγ receptors (FcγRs) are key immune receptors responsible for the effective control of both
humoral and innate immunity and are central to maintaining the balance between …

Divergent evolution for more than 310 million years has resulted in an avian immune system
that is complex and more compact than that of primates, sharing much of its structure and …

Genomic structural variants (SVs) are distributed nonrandomly across the human genome.
The “hotspots” of SVs have been implicated in evolutionary innovations, as well as medical …

Recurrent rearrangements of Chromosome 8p23. 1 are associated with congenital heart
defects and developmental delay. The complexity of this region has led to inconsistencies in …

Copy number variation (CNV) is a major proportion of genetic variation, which changes the
gene structure and dosage and affects gene expression and function. To validate the …

Convergent evolution, where independent lineages evolve similar phenotypes in response
to similar challenges, can provide valuable insight into how selection operates and the …

β-Defensins are peptides with antimicrobial roles, characterized by a conserved tertiary
structure. Beyond antimicrobial functions, they exhibit diverse roles in both the immune …