Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

L Perico, A Benigni, F Casiraghi, LFP Ng… - Nature Reviews …, 2021 - nature.com
In December 2019, a novel coronavirus was isolated from the respiratory epithelium of
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …

Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19

W Ni, X Yang, D Yang, J Bao, R Li, Y Xiao, C Hou… - Critical Care, 2020 - Springer
An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global …

Extrapulmonary manifestations of COVID-19

A Gupta, MV Madhavan, K Sehgal, N Nair… - Nature medicine, 2020 - nature.com
Although COVID-19 is most well known for causing substantial respiratory pathology, it can
also result in several extrapulmonary manifestations. These conditions include thrombotic …

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

T Mokhtari, F Hassani, N Ghaffari, B Ebrahimi… - Journal of molecular …, 2020 - Springer
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in
December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) …

Covid‐19 and kidney injury: Pathophysiology and molecular mechanisms

E Ahmadian, SM Hosseiniyan Khatibi… - Reviews in medical …, 2021 - Wiley Online Library
The novel coronavirus (SARS‐CoV‐2) has turned into a life‐threatening pandemic disease
(Covid‐19). About 5% of patients with Covid‐19 have severe symptoms including septic …

Mechanisms in endocrinology: vitamin D and COVID-19

JP Bilezikian, D Bikle, M Hewison… - European journal of …, 2020 - academic.oup.com
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has generated an explosion
of interest both in the mechanisms of infection leading to dissemination and expression of …

Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19

JH Ahn, JM Kim, SP Hong, SY Choi… - The Journal of …, 2021 - Am Soc Clin Investig
The upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-
2 tropism at the cellular level is not fully defined. Unlike recent single-cell RNA-Seq analyses …

Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence

C Sardu, J Gambardella, MB Morelli, X Wang… - Journal of clinical …, 2020 - mdpi.com
The symptoms most commonly reported by patients affected by coronavirus disease (COVID-
19) include cough, fever, and shortness of breath. However, other major events usually …

Acute kidney injury in COVID-19: emerging evidence of a distinct pathophysiology

D Batlle, MJ Soler, MA Sparks, S Hiremath… - Journal of the …, 2020 - journals.lww.com
The most common reported reasons for intensive care unit admission for patients with
severe coronavirus disease 2019 (COVID-19) are either hypoxemic respiratory failure …

Should COVID-19 concern nephrologists? Why and to what extent? The emerging impasse of angiotensin blockade

L Perico, A Benigni, G Remuzzi - Nephron, 2020 - karger.com
Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney
diseases, including acute kidney injury, and examine the potential effects of ARBs on the …