Background Cellular senescence, a permanent state of replicative arrest in otherwise
proliferating cells, is a hallmark of aging and has been linked to aging-related diseases …

Androgen deprivation therapy is a cornerstone of treatment for advanced prostate cancer,
and the development of castrate-resistant prostate cancer (CRPC) is the primary cause of …

The reprimo (RPRM) gene family is a group of single exon genes present exclusively within
the vertebrate lineage. Two out of three members of this family are present in humans …

Reprimo (RPRM), a target gene of p53, is a known tumor suppressor. DNA damage induces
RPRM, which triggers p53‐dependent G2 arrest by inhibiting cyclin B1/Cdc2 complex …

Reprimo-like (RPRML) is an uncharacterized member of the Reprimo gene family. Here, we
evaluated the role of RPRML and whether its regulation by DNA methylation is a potential …

Gastric cancer (GC) as an aggressive malignancy still causes a global health problem. It has
been documented that long noncoding RNAs are involved in GC development. Therefore …

Background The development of the amniote limb has been an important model system to
study patterning mechanisms and morphogenesis. For proper growth and patterning, it …

Evolutionary studies of genes that have been functionally characterized and whose variation
has been associated with pathological conditions represent an opportunity to understand …

Rat offspring who are exposed to an amorphous formula of curcumin (CUR) from the
embryonic stage have anti-anxiety-like behaviors, enhanced fear extinction learning, and …

The study of the evolutionary history of genes related to human disease lies at the interface
of evolution and medicine. These studies provide the evolutionary context on which medical …