Alternative splicing is a substantial contributor to the high complexity of transcriptomes of
multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of …

A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …

High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Over the past few decades, substantial evidence has convincingly revealed the existence of
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …

Polyploidization has provided much genetic variation for plant adaptive evolution, but the
mechanisms by which the molecular evolution of polyploid genomes establishes genetic …

Measuring gene expression in individual cells is crucial for understanding the gene
regulatory network controlling human embryonic development. Here we apply single-cell …

In this study, we present integrated quantitative proteome, transcriptome, and methylome
analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) …

Accumulating evidence indicates that circular RNAs (circRNAs) are abundant in the human
transcriptome. However, their involvement in biological processes, including pluripotency …

Alternative splicing was discovered simultaneously with splicing over three decades ago.
Since then, an enormous body of evidence has demonstrated the prevalence of alternative …

Most human genes generate multiple transcript isoforms. The differential expression of these
isoforms can help specify cell types. Diverse transcript isoforms arise from the use of …