Intrahepatic cholangiocarcinoma (iCCA) has over the last 10‐20 years become the focus of
increasing concern, largely due to its rising incidence and high mortality rates worldwide …

In conjunction with the classical functions of regulating intestinal, bone, and kidney calcium
and phosphorus absorption, as well as bone mineralization of vitamin D, the population …

Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we
mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination …

TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate
immune cells encounter different mechanical cues in both health and disease to adapt their …

Inflammation, epithelial cell regeneration, macrophage polarization, and gut microbial
homeostasis are critical for the pathological processes associated with inflammatory bowel …

Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism
against pathogens. However, the cellular self-protective mechanism against such potential …

The transcription coactivator YAP plays a vital role in Hippo pathway for organ-size control
and tissue homeostasis. Recent studies have demonstrated YAP is closely related to …

An imbalance in the lineages of immunosuppressive regulatory T cells (Treg cells) and the
inflammatory TH17 subset of helper T cells leads to the development of autoimmune and/or …

Red blood cell (RBC)-mimicking nanoparticles (NPs) offer a promising platform for drug
delivery because of their prolonged circulation time, reduced immunogenicity and specific …

Recognition of pathogen-associated molecular patterns (PAMPs) triggers expression of
antiviral interferons and proinflammatory cytokines, which functions as the frontier of host …