Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology

R Altman, B Bosch, K Brune, P Patrignani, C Young - Drugs, 2015 - Springer
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class
with anti-inflammatory, analgesic, and antipyretic properties. Contrary to the action of many …

Adverse drug reactions and drug–drug interactions with over-the-counter NSAIDs

N Moore, C Pollack, P Butkerait - Therapeutics and clinical risk …, 2015 - Taylor & Francis
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen have a long history of safe
and effective use as both prescription and over-the-counter (OTC) analgesics/antipyretics …

[图书][B] Deadly medicines and organised crime: how big pharma has corrupted healthcare

P Gotzsche - 2019 - taylorfrancis.com
PRESCRIPTION DRUGS ARE THE THIRD LEADING CAUSE OF DEATH AFTER HEART
DISEASE AND CANCER. In his latest ground-breaking book, Peter C Gotzsche exposes the …

Prevalence and patterns of multimorbidity in a nationally representative sample of older Chinese: results from the China health and retirement longitudinal study

SS Yao, GY Cao, L Han, ZS Chen… - The Journals of …, 2020 - academic.oup.com
Background Multimorbidity has become a prominent problem worldwide; however, few
population-based studies have been conducted among older Chinese with multimorbidity …

Use of non-steroidal anti-inflammatory drugs that elevate cardiovascular risk: an examination of sales and essential medicines lists in low-, middle-, and high-income …

P McGettigan, D Henry - PLoS medicine, 2013 - journals.plos.org
Background Certain non-steroidal anti-inflammatory drugs (NSAIDs)(eg, rofecoxib [Vioxx])
increase the risk of heart attack and stroke and should be avoided in patients at high risk of …

Ibuprofen safety at the golden anniversary: are all NSAIDs the same? A narrative review

G Varrassi, JV Pergolizzi, P Dowling, A Paladini - Advances in therapy, 2020 - Springer
Ibuprofen first came to market about 50 years ago and rapidly moved to over-the-counter
(OTC) sales. In April 2019, the National Agency for the Safety of Medicines and Health …

Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies

P McGettigan, D Henry - PLoS medicine, 2011 - journals.plos.org
Background Randomised trials have highlighted the cardiovascular risks of non-steroidal
anti-inflammatory drugs (NSAIDs) in high doses and sometimes atypical settings. Here, we …

Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled …

FE Silverstein, G Faich, JL Goldstein, LS Simon… - Jama, 2000 - jamanetwork.com
ContextConventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a
spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of …

Ibuprofen: pharmacology, efficacy and safety

KD Rainsford - Inflammopharmacology, 2009 - Springer
Objectives This review attempts to bring together information from a large number of recent
studies on the clinical uses, safety and pharmacological properties of ibuprofen. Ibuprofen is …

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis

TD Warner, F Giuliano, I Vojnovic… - Proceedings of the …, 1999 - National Acad Sciences
The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with
inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with …