Replication fork reversal is a rapidly emerging and remarkably frequent mechanism of fork
stabilization in response to genotoxic insults. Here, we summarize recent findings that …

A large number of SNF2 family, DNA and ATP-dependent motor proteins are needed during
transcription, DNA replication, and DNA repair to manipulate protein–DNA interactions and …

DNA replication stress can stall replication forks, leading to genome instability. DNA damage
tolerance pathways assist fork progression, promoting replication fork reversal, translesion …

To ensure the completion of DNA replication and maintenance of genome integrity, DNA
repair factors protect stalled replication forks upon replication stress. Previous studies have …

Using CRISPR-Cas9 nicking enzymes, we examined the interaction between the replication
machinery and single-strand breaks, one of the most common forms of endogenous DNA …

Stalled replication forks are a critical problem for the cell because they can lead to complex
genome rearrangements that underlie cell death and disease. Processes such as DNA …

DNA damage tolerance and mutagenesis are hallmarks and enabling characteristics of
neoplastic cells that drive tumorigenesis and allow cancer cells to resist therapy. The 'Y …

A universal response to replication stress is replication fork reversal, where the nascent
complementary DNA strands are annealed to form a protective four-way junction allowing …

During evolution, cells have developed a wide spectrum of stress response modules to
ensure homeostasis. The genome and proteome damage response pathways constitute the …

DNA replication is laden with obstacles that slow, stall, collapse, and break DNA replication
forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair …