Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

F Veglia, E Sanseviero, DI Gabrilovich - Nature Reviews Immunology, 2021 - nature.com
Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and
monocytes with potent immunosuppressive activity. They are implicated in the regulation of …

The Yin and Yang of myeloid derived suppressor cells

S Budhwar, P Verma, R Verma, S Rai… - Frontiers in …, 2018 - frontiersin.org
In recent years, most of our knowledge about myeloid derived suppressor cells (MDSCs)
has come from cancer studies, which depicts Yin side of MDSCs. In cancer, inherent …

Human leukocyte immunoglobulin-like receptors in health and disease

S Redondo-García, C Barritt, C Papagregoriou… - Frontiers in …, 2023 - frontiersin.org
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) are a family of 11 innate
immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are …

Leukocyte immunoglobulin-like receptor subfamily B: therapeutic targets in cancer

M Deng, H Chen, X Liu, R Huang, Y He… - Antibody …, 2021 - academic.oup.com
Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1–5) transduce signals via
intracellular immunoreceptor tyrosine-based inhibitory motifs that recruit phosphatases to …

[HTML][HTML] Role of myeloid-derived suppressor cells in the promotion and immunotherapy of colitis-associated cancer

Y Wang, Y Ding, Y Deng, Y Zheng… - … for Immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Colitis-associated cancer (CAC) is a specific type of colorectal cancer that develops from
inflammatory bowel disease (IBD). Myeloid-derived suppressor cells (MDSCs) are a …

Myeloid‐derived suppressor cells in the therapy of autoimmune diseases

M Bekić, S Tomić - European Journal of Immunology, 2023 - Wiley Online Library
Myeloid‐derived suppressor cells (MDSCs) are well recognized as critical factors in the
pathology of tumors. However, their roles in autoimmune diseases are still unclear, which …

Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

C van Geffen, C Heiss, A Deißler… - Frontiers in …, 2022 - frontiersin.org
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent
suppressive and regulative properties. MDSCs' strong immunosuppressive potential creates …

Myeloid-derived suppressor cells as cellular immunotherapy in transplantation and autoimmune diseases

J Zhang, A Hodges, SH Chen, PY Pan - Cellular immunology, 2021 - Elsevier
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells, which have been characterized for their immunosuppressive capacity through …

Human inhibitory leukocyte Ig-like receptors: from immunotolerance to immunotherapy

A Roghanian, C De Louche - JCI insight, 2022 - eprints.soton.ac.uk
In recent decades, immunotherapeutic strategies have been used to treat a wide range of
pathologies, many of which were previously incurable, such as cancer and autoimmune …

Understanding regulatory B cells in autoimmune diseases: the case of multiple sclerosis

BT Cuc, J Pohar, S Fillatreau - Current opinion in immunology, 2019 - Elsevier
Highlights•B cells have regulatory functions in EAE and MS through IL-10 production.•The
differentiation of IL-10-producing B cells is associated to plasmocytes formation.• …