Over the past two decades, elucidation of the genetic defects that underlie cancer has
resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be …

Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …

Every cancer originates from a single cell. During expansion of the neoplastic cell
population, individual cells acquire genetic and phenotypic differences from each other …

Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations
determining the clinicobiological behaviour are not fully understood. Here we describe a …

Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor
genotype variations among tumors within different patients are known as interpatient …

Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

Immune dysregulation is a cardinal feature of chronic lymphocytic leukemia (CLL) from its
early stage and worsens during clinical observation, even in absence of disease …

Neuroblastoma is a malignancy of the developing sympathetic nervous system that is often
lethal when relapse occurs. We here used whole-exome sequencing, mRNA expression …

Charting differences between tumors and normal tissue is a mainstay of cancer research.
However, clonal tumor expansion from complex normal tissue architectures potentially …

Chronic lymphocytic leukemia is a well-defined lymphoid neoplasm with very
heterogeneous biological and clinical behavior. The last decade has been remarkably …