Objective To discuss how hypoxaemia might be harmful and why horses are particularly
predisposed to developing it, to review the strategies that are used to manage hypoxaemia …

Lung alveolar epithelial cells are normally very well oxygenated but may be exposed to
hypoxia in many pathological conditions such as pulmonary edema, acute respiratory …

Sepsis-related acute lung injury (ALI) is characterized by excessive lung inflammation and
apoptosis of alveolar epithelial cells resulting in acute hypoxemic respiratory failure. Recent …

Transcription factor Krüppel-like factors 5 (KLF5) is overexpressed in a wide range of tumor
tissues and acts as a prognostic factor in cancer. However, the role of KLF5 in non-small cell …

Acute lung injury (ALI) is a severe disease with high morbidity and mortality, and is
characterized by devastating inflammation of the lung and increased production of reactive …

Objectives: Excessive oxidative stress is a main cause of lung ischemia-reperfusion injury,
which often results in respiratory insufficiency after open-heart surgery for a …

The hedgehog signal pathway plays a crucial role in the angiogenesis and vascular
remodeling. However, the function of this pathway in the pulmonary vascular smooth cell …

Background Pulmonary surfactant oxidation leads to alveolar collapse-a condition often
noticed in high altitude pulmonary edema (HAPE). The present study was aimed to …

Objectives Periodontitis is induced by the imbalance between osteoblast and osteoclast
activity, which leads to periodontal tissue destruction. Macrophages play a vital role in …

Alveolar type II (ATII) respiratory epithelial cells are essential to normal lung function. They
may be also central to the pathogenesis of diseases such as acute lung injury, pulmonary …