All living organisms have developed processes to sense and address environmental
changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour …

Background Hypoxia has long been considered as a hallmark of solid tumors and is closely
associated with tumor progression. Circular RNAs (circRNAs) have been identified as a …

An increasing number of noncoding RNAs (ncRNAs) have been found to regulate gene
expression and protein functions, playing important roles in diverse biological processes …

Circular RNAs (circRNAs) play a crucial role in cancer development and progression. This
study aimed to identify potential circRNA biomarkers for osteosarcoma. Articles published …

Pigs are playing an increasingly vital role as translational biomedical models for studying
human pathophysiology. The annotation of the pig genome was a huge step forward in …

p53 is the most commonly mutated gene in human cancers. Two fundamental reasons for
this are its long protein isoforms protect from cancer, while its shorter C-terminal isoforms …

Osteosarcoma is the most common malignant tumor in adolescent bone malignancies. It has
the characteristics of a high metastasis rate, high mortality and poor prognosis. As a …

Abstract Objective Circular RNAs (circRNAs) play important roles in modulating tumour
progression. This study investigated the role of circ_0000253 in osteosarcoma (OS) …

Simple Summary Research in large animal models has been hampered by the complexity to
introduce new gene alterations, but this has been simplified by the discovery of the …

The current COVID-19 pandemic is caused by infections with the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). A sex-bias has been observed, with increased …