In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices

M Kotecha, L Wang, S Hameed, N Viswakarma… - Scientific Reports, 2023 - nature.com
Abstract Type 1 diabetes (T1D) is an autoimmune disease that leads to the loss of insulin-
producing beta cells. Bioartificial pancreas (BAP) or beta cell replacement strategies have …

Advances in the Use of Biologics and Biomaterials toward the Improvement of Pancreatic Islet Graft Survival in Type 1 Diabetes

MY Yitayew, M Luginina… - Advanced NanoBiomed …, 2024 - Wiley Online Library
Islet transplantation is a curative treatment for patients suffering from type 1 diabetes and
has the potential to replace current treatment strategies involving the exogenous …

Engineering Vascularized Islet Macroencapsulation Devices: An in vitro Platform to Study Oxygen Transport in Perfused Immobilized Pancreatic Beta Cell Cultures

F SA, C KS, L RL, H CA - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Islet encapsulation devices serve to deliver pancreatic beta cells to type 1 diabetic patients
without the need for chronic immunosuppression. However, clinical translation is hampered …

Exploring therapy transport from implantable medical devices using experimentally informed computational methods

L Trask, NA Ward, R Tarpey, R Beatty, E Wallace… - Biomaterials …, 2024 - pubs.rsc.org
Implantable medical devices that can facilitate therapy transport to localized sites are being
developed for a number of diverse applications, including the treatment of diseases such as …

Improving the 3D printability of sugar glass to engineer sacrificial vascular templates

BN Moeun, SA Fernandez, S Collin… - 3D Printing and …, 2023 - liebertpub.com
A prominent obstacle in scaling up tissue engineering technologies for human applications
is engineering an adequate supply of oxygen and nutrients throughout artificial tissues …

A thin disc-shaped macrocapsule for transplantation of oxygen carrier-laden alginate hydrogel-encapsulated pancreatic islets in diabetic mice

N Kakaei, Z Izadi, G Mohammadi, A Ahmadi… - Materials …, 2024 - pubs.rsc.org
Pancreatic islet encapsulation has long been considered as a groundbreaking solution
capable of reducing dependence on lengthy immune suppression protocols while boosting …