Biological clocks as age estimation markers in animals: a systematic review and meta‐analysis

LS Le Clercq, A Kotzé, JP Grobler… - Biological …, 2023 - Wiley Online Library
Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …

A mammalian methylation array for profiling methylation levels at conserved sequences

A Arneson, A Haghani, MJ Thompson… - Nature …, 2022 - nature.com
Infinium methylation arrays are not available for the vast majority of non-human mammals.
Moreover, even if species-specific arrays were available, probe differences between them …

Universal DNA methylation age across mammalian tissues

AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li… - Nature aging, 2023 - nature.com
Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

Universal DNA methylation age across mammalian tissues

AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li… - BioRxiv, 2021 - biorxiv.org
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …

Harnessing male germline epigenomics for the genetic improvement in cattle

X Wang, W Li, X Feng, J Li, GE Liu, L Fang… - Journal of animal science …, 2023 - Springer
Sperm is essential for successful artificial insemination in dairy cattle, and its quality can be
influenced by both epigenetic modification and epigenetic inheritance. The bovine germline …

DNA methylation aging and transcriptomic studies in horses

S Horvath, A Haghani, S Peng, EN Hales… - Nature …, 2022 - nature.com
Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we
profile n= 333 samples from 42 horse tissue types at loci that are highly conserved between …

DNA methylation‐based biomarkers for ageing long‐lived cetaceans

KM Parsons, A Haghani, JA Zoller… - Molecular ecology …, 2023 - Wiley Online Library
Epigenetic approaches for estimating the age of living organisms are revolutionizing studies
of long‐lived species. Molecular biomarkers that allow age estimates from small tissue …

Multi-tissue DNA methylation aging clocks for sea lions, walruses and seals

TR Robeck, A Haghani, Z Fei, DM Lindemann… - Communications …, 2023 - nature.com
Age determination of wild animals, including pinnipeds, is critical for accurate population
assessment and management. For most pinnipeds, current age estimation methodologies …

DNA methylation networks underlying mammalian traits

A Haghani, CZ Li, TR Robeck, J Zhang, AT Lu… - Science, 2023 - science.org
Using DNA methylation profiles (n= 15,456) from 348 mammalian species, we constructed
phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using …

Epigenetic aging in cows is accelerated by milk production

P Ratan, L Rubbi, M Thompson, K Naresh, J Waddell… - Epigenetics, 2023 - Taylor & Francis
ABSTRACT DNA methylation has proven to be the most promising age-predictive biomarker
in mammals resulting in the emergence of 'epigenetic clocks' that describe the relationship …