The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Acute graft-versus-host disease (GVHD) is a common immune complication that can occur
after allogeneic haematopoietic cell transplantation (alloHCT). Acute GVHD is a major …

Background Chronic graft-versus-host disease (GVHD), a major complication of allogeneic
stem-cell transplantation, becomes glucocorticoid-refractory or glucocorticoid-dependent in …

Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

Background Accumulating evidence proposed Janus-associated kinase (JAK) inhibitors as
therapeutic targets warranting rapid investigation. Objective This study evaluated the …

The therapeutic potential of donor-derived mesenchymal stromal cells (MSCs) has been
investigated in diverse diseases, including steroid-resistant acute graft versus host disease …

Background Acute graft-versus-host disease (GVHD) remains a major limitation of
allogeneic stem-cell transplantation; not all patients have a response to standard …

A subgroup of patients with severe COVID-19 suffers from progression to acute respiratory
distress syndrome and multiorgan failure. These patients present with progressive …

In the rapidly evolving coronavirus disease (COVID-19) pandemic, repurposing existing
drugs and evaluating commercially available inhibitors against druggable targets of the virus …

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome corona virus 2 (SARS-CoV-2), continues to spread globally despite …