Tau protein kinases: involvement in Alzheimer's disease
Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …
[HTML][HTML] The importance of tau phosphorylation for neurodegenerative diseases
Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several
neurodegenerative tauopathies including Alzheimer's disease (AD) and some …
neurodegenerative tauopathies including Alzheimer's disease (AD) and some …
[HTML][HTML] Phosphorylation of different tau sites during progression of Alzheimer's disease
J Neddens, M Temmel, S Flunkert… - Acta neuropathologica …, 2018 - Springer
Alzheimer's disease is characterized by accumulation of amyloid plaques and tau
aggregates in several cortical brain regions. Tau phosphorylation causes formation of …
aggregates in several cortical brain regions. Tau phosphorylation causes formation of …
Targeted dephosphorylation of tau by phosphorylation targeting chimeras (PhosTACs) as a therapeutic modality
Microtubule-associated protein tau is essential for microtubule assembly and stabilization.
Hyperphosphorylation of the microtubule-associated protein tau plays an important …
Hyperphosphorylation of the microtubule-associated protein tau plays an important …
[HTML][HTML] Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer's disease? From preclinical studies to the clinical …
Protein kinases (PKs) have emerged as one of the most intensively investigated drug targets
in current pharmacological research, with indications ranging from oncology to …
in current pharmacological research, with indications ranging from oncology to …
Post-translational modifications of tau protein: implications for Alzheimer's disease
L Martin, X Latypova, F Terro - Neurochemistry international, 2011 - Elsevier
Alzheimer's disease (AD) belongs to a group of neurodegenerative diseases collectively
designated as “tauopathies”, because they are characterized by the aggregation of …
designated as “tauopathies”, because they are characterized by the aggregation of …
Amyloid-β/Fyn–induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease
ED Roberson, B Halabisky, JW Yoo, J Yao… - Journal of …, 2011 - Soc Neuroscience
Alzheimer's disease (AD), the most common neurodegenerative disorder, is a growing
public health problem and still lacks effective treatments. Recent evidence suggests that …
public health problem and still lacks effective treatments. Recent evidence suggests that …
[HTML][HTML] Role of tau protein in both physiological and pathological conditions
J Avila, JJ Lucas, MAR Perez… - Physiological …, 2004 - journals.physiology.org
Abstract Avila, Jesús, José J. Lucas, Mar Pérez, and Félix Hernández. Role of Tau Protein in
Both Physiological and Pathological Conditions. Physiol Rev 84: 361–384, 2004; …
Both Physiological and Pathological Conditions. Physiol Rev 84: 361–384, 2004; …
[HTML][HTML] The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?
Abstract A strong genetic predisposition (60–80% of attributable risk) is present in
Alzheimer's disease (AD). In view of this major genetic component, identification of the …
Alzheimer's disease (AD). In view of this major genetic component, identification of the …
[HTML][HTML] The role of tau in neurodegeneration
TF Gendron, L Petrucelli - Molecular neurodegeneration, 2009 - Springer
Since the identification of tau as the main component of neurofibrillary tangles in Alzheimer's
disease and related tauopathies, and the discovery that mutations in the tau gene cause …
disease and related tauopathies, and the discovery that mutations in the tau gene cause …