[HTML][HTML] A comprehensive review on MAPK: a promising therapeutic target in cancer
The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
[HTML][HTML] Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy
U Degirmenci, M Wang, J Hu - Cells, 2020 - mdpi.com
The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …
cellular communication, which regulates fundamental cell functions such as growth, survival …
Regulation of RAF protein kinases in ERK signalling
H Lavoie, M Therrien - Nature reviews Molecular cell biology, 2015 - nature.com
RAF family kinases were among the first oncoproteins to be described more than 30 years
ago. They primarily act as signalling relays downstream of RAS, and their close ties to …
ago. They primarily act as signalling relays downstream of RAS, and their close ties to …
Regulation of body size and growth control
The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …
size and proportions, which is important for survival and reproduction. In animals, adult body …
Upstream and downstream of mTOR
N Hay, N Sonenberg - Genes & development, 2004 - genesdev.cshlp.org
The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has
emerged as a major effector of cell growth and proliferation via the regulation of protein …
emerged as a major effector of cell growth and proliferation via the regulation of protein …
The tuberous sclerosis complex
PB Crino, KL Nathanson… - New England Journal of …, 2006 - Mass Medical Soc
The tuberous sclerosis complex (TSC), a multisystem, autosomal dominant disorder
affecting children and adults, results from mutations in one of two genes, TSC1 (encoding …
affecting children and adults, results from mutations in one of two genes, TSC1 (encoding …
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
J Huang, BD Manning - Biochemical Journal, 2008 - portlandpress.com
TSC1 and TSC2 are the tumour-suppressor genes mutated in the tumour syndrome TSC
(tuberous sclerosis complex). Their gene products form a complex that has become the …
(tuberous sclerosis complex). Their gene products form a complex that has become the …
[HTML][HTML] Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
A Carracedo, L Ma, J Teruya-Feldstein… - The Journal of …, 2008 - Am Soc Clin Investig
Numerous studies have established a causal link between aberrant mammalian target of
rapamycin (mTOR) activation and tumorigenesis, indicating that mTOR inhibition may have …
rapamycin (mTOR) activation and tumorigenesis, indicating that mTOR inhibition may have …
[HTML][HTML] Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
Abstract Background: Tuberous Sclerosis Complex (TSC) is a genetic disorder that occurs
through the loss of heterozygosity of either TSC1 or TSC2, which encode Hamartin or …
through the loss of heterozygosity of either TSC1 or TSC2, which encode Hamartin or …
The PTEN–PI3K pathway: of feedbacks and cross-talks
A Carracedo, PP Pandolfi - Oncogene, 2008 - nature.com
The tumor suppressor PTEN was originally identified as a negative regulator of the
phosphoinositide 3-kinase (PI3K) signaling, a main regulator of cell growth, metabolism and …
phosphoinositide 3-kinase (PI3K) signaling, a main regulator of cell growth, metabolism and …