Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Cancer stem cells (CSCs) have important roles in tumour development, relapse and
metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells …

Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

Oncogenesis often implicates epigenetic alterations, including derepression of transposable
elements (TEs) and defects in alternative splicing. Here, we explore the possibility that …

WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Most tumor cells express antigens that can mediate recognition by host CD8+ T cells.
Cancers that are detected clinically must have evaded antitumor immune responses to grow …

Metabolic reprogramming is a hallmark of cancer. However, it is not well known how
metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA …

Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our
appreciation for the complex roles for WNT signalling pathways in cancer has increased …

β‐Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule
that in metazoans exerts a crucial role in a multitude of developmental and homeostatic …