The multiple mechanisms that regulate p53 activity and cell fate
A Hafner, ML Bulyk, A Jambhekar… - Nature reviews Molecular …, 2019 - nature.com
The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
The broken cycle: E2F dysfunction in cancer
LN Kent, G Leone - Nature Reviews Cancer, 2019 - nature.com
The cyclin-dependent kinase (CDK)–RB–E2F axis forms the core transcriptional machinery
driving cell cycle progression, dictating the timing and fidelity of genome replication and …
driving cell cycle progression, dictating the timing and fidelity of genome replication and …
[HTML][HTML] Mechanisms of transcriptional regulation by p53
Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …
dozens of target genes with diverse biological functions. The activity of this master …
α-Ketoglutarate links p53 to cell fate during tumour suppression
JP Morris IV, JJ Yashinskie, R Koche, R Chandwani… - Nature, 2019 - nature.com
The tumour suppressor TP53 is mutated in the majority of human cancers, and in over 70%
of pancreatic ductal adenocarcinoma (PDAC),. Wild-type p53 accumulates in response to …
of pancreatic ductal adenocarcinoma (PDAC),. Wild-type p53 accumulates in response to …
Forging a signature of in vivo senescence
NE Sharpless, CJ Sherr - Nature Reviews Cancer, 2015 - nature.com
Abstract'Cellular senescence', a term originally defining the characteristics of cultured cells
that exceed their replicative limit, has been broadened to describe durable states of …
that exceed their replicative limit, has been broadened to describe durable states of …
Senescence and aging: the critical roles of p53
Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …
Tumor-suppressor functions of the TP53 pathway
BJ Aubrey, A Strasser, GL Kelly - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
The fundamental biological importance of the Tp53 gene family is highlighted by its
evolutionary conservation for more than one billion years dating back to the earliest …
evolutionary conservation for more than one billion years dating back to the earliest …
The DREAM complex: master coordinator of cell cycle-dependent gene expression
S Sadasivam, JA DeCaprio - Nature Reviews Cancer, 2013 - nature.com
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F …
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F …
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and
malignant disease. Cellular models of RAS-dependent cancers have been used to identify …
malignant disease. Cellular models of RAS-dependent cancers have been used to identify …
[HTML][HTML] p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer
DF Tschaharganeh, W Xue, DF Calvisi, M Evert… - Cell, 2014 - cell.com
The p53 tumor suppressor coordinates a series of antiproliferative responses that restrict the
expansion of malignant cells, and as a consequence, p53 is lost or mutated in the majority of …
expansion of malignant cells, and as a consequence, p53 is lost or mutated in the majority of …