The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …

The cyclin-dependent kinase (CDK)–RB–E2F axis forms the core transcriptional machinery
driving cell cycle progression, dictating the timing and fidelity of genome replication and …

Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …

The tumour suppressor TP53 is mutated in the majority of human cancers, and in over 70%
of pancreatic ductal adenocarcinoma (PDAC),. Wild-type p53 accumulates in response to …

Abstract'Cellular senescence', a term originally defining the characteristics of cultured cells
that exceed their replicative limit, has been broadened to describe durable states of …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

The fundamental biological importance of the Tp53 gene family is highlighted by its
evolutionary conservation for more than one billion years dating back to the earliest …

The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F …

Activated RAS GTPase signalling is a critical driver of oncogenic transformation and
malignant disease. Cellular models of RAS-dependent cancers have been used to identify …

The p53 tumor suppressor coordinates a series of antiproliferative responses that restrict the
expansion of malignant cells, and as a consequence, p53 is lost or mutated in the majority of …