Taxol is a potent drug used in various cancer treatments. Its complex structure has prompted
extensive research into its biosynthesis. However, certain critical steps, such as the …

Highlights•Plant-derived compounds remain vital in modern pharmacology and drug
discovery.•Microbes are versatile screening systems for prospecting biosynthetic plant …

Elucidating the biochemical pathways of specialised metabolites in plants is key to enable or
improve their sustainable biotechnological production. Chemical tools can greatly facilitate …

While sanguinarine has gained recognition for antimicrobial and antineoplastic activities, its
complex conjugated structure and low abundance in plants impede broad applications …

Highlights•Microbial expression systems for sustainable production of plant natural
products.•Multiplex genome editing for rapid construction of complex PNP biosynthetic …

Plant metabolite profiling reveals the diversity of secondary or specialized metabolites in the
plant kingdom with its hundreds of thousands of species. Specialized plant metabolites …

Obesity is a chronic metabolic disease mainly caused by fat accumulation. Well-recognized
anti-obesity therapies are lacking. Celastrol is a bioactive small-molecule drug extracted …

Abstract Cembratriene-ol (CBT-ol), a plant-derived macrocyclic diterpene with notable
insecticidal activity, has attracted considerable attention with respect to the development of …

Microbial factories lacking the ability of dynamically regulating the pathway enzymes
overexpression, according to in situ metabolite concentrations, are suboptimal, especially …

Celastrol is a bioactive pentacyclic triterpenoid with promising therapeutic effects that is
mainly distributed in Celastraceae plants. Although some enzymes involved in the celastrol …