Systems biology in cardiovascular disease: a multiomics approach
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …
new informatics approaches alongside conventional statistical methods. Systems theories …
MicroRNAs in cardiovascular disease
Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …
RNA-Seq identifies circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as potential biomarkers for acute ischemic stroke
Rationale: Currently, there are no blood-based biomarkers with clinical utility for acute
ischemic stroke (IS). MicroRNAs show promise as disease markers because of their cell type …
ischemic stroke (IS). MicroRNAs show promise as disease markers because of their cell type …
Association of cardiometabolic microRNAs with COVID-19 severity and mortality
C Gutmann, K Khamina, K Theofilatos… - Cardiovascular …, 2022 - academic.oup.com
Abstract Aims Coronavirus disease 2019 (COVID-19) can lead to multiorgan damage.
MicroRNAs (miRNAs) in blood reflect cell activation and tissue injury. We aimed to …
MicroRNAs (miRNAs) in blood reflect cell activation and tissue injury. We aimed to …
Impact of miRNA in atherosclerosis
e160 Arterioscler Thromb Vasc Biol September 2018 were actively exported to the
cytoplasm with exportin-5 in a Ran-GTP–dependent manner. In the cytoplasm, the transition …
cytoplasm with exportin-5 in a Ran-GTP–dependent manner. In the cytoplasm, the transition …
MicroRNA biomarkers and platelet reactivity: the clot thickens
N Sunderland, P Skroblin, T Barwari… - Circulation …, 2017 - Am Heart Assoc
Over the last few years, several groups have evaluated the potential of microRNAs
(miRNAs) as biomarkers for cardiometabolic disease. In this review, we discuss the …
(miRNAs) as biomarkers for cardiometabolic disease. In this review, we discuss the …
Novel risk markers and risk assessments for cardiovascular disease
The use of risk markers has transformed cardiovascular medicine, exemplified by the routine
assessment of troponin, for both diagnosis and assessment of prognosis in patients with …
assessment of troponin, for both diagnosis and assessment of prognosis in patients with …
Fibrin clot properties independently predict adverse clinical outcome following acute coronary syndrome: a PLATO substudy
Aims To determine whether fibrin clot properties are associated with clinical outcomes
following acute coronary syndrome (ACS). Methods and results Plasma samples were …
following acute coronary syndrome (ACS). Methods and results Plasma samples were …
Platelet-derived microRNAs regulate cardiac remodeling after myocardial ischemia
JP Schütte, MC Manke, K Hemmen, P Münzer… - Circulation …, 2023 - Am Heart Assoc
Background: Platelets can infiltrate ischemic myocardium and are increasingly recognized
as critical regulators of inflammatory processes during myocardial ischemia and reperfusion …
as critical regulators of inflammatory processes during myocardial ischemia and reperfusion …
Platelets in cardiac ischaemia/reperfusion injury: a promising therapeutic target
Acute myocardial infarction (AMI) is the single leading cause of mortality and morbidity
worldwide. A key component of AMI therapy is the timely reopening of occluded vessels to …
worldwide. A key component of AMI therapy is the timely reopening of occluded vessels to …