Systems biology in cardiovascular disease: a multiomics approach

A Joshi, M Rienks, K Theofilatos, M Mayr - Nature Reviews Cardiology, 2021 - nature.com
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …

MicroRNAs in cardiovascular disease

T Barwari, A Joshi, M Mayr - Journal of the American College of Cardiology, 2016 - jacc.org
Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …

RNA-Seq identifies circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as potential biomarkers for acute ischemic stroke

S Tiedt, M Prestel, R Malik, N Schieferdecker… - Circulation …, 2017 - Am Heart Assoc
Rationale: Currently, there are no blood-based biomarkers with clinical utility for acute
ischemic stroke (IS). MicroRNAs show promise as disease markers because of their cell type …

Association of cardiometabolic microRNAs with COVID-19 severity and mortality

C Gutmann, K Khamina, K Theofilatos… - Cardiovascular …, 2022 - academic.oup.com
Abstract Aims Coronavirus disease 2019 (COVID-19) can lead to multiorgan damage.
MicroRNAs (miRNAs) in blood reflect cell activation and tissue injury. We aimed to …

Impact of miRNA in atherosclerosis

Y Lu, T Thavarajah, W Gu, J Cai… - … , thrombosis, and vascular …, 2018 - Am Heart Assoc
e160 Arterioscler Thromb Vasc Biol September 2018 were actively exported to the
cytoplasm with exportin-5 in a Ran-GTP–dependent manner. In the cytoplasm, the transition …

MicroRNA biomarkers and platelet reactivity: the clot thickens

N Sunderland, P Skroblin, T Barwari… - Circulation …, 2017 - Am Heart Assoc
Over the last few years, several groups have evaluated the potential of microRNAs
(miRNAs) as biomarkers for cardiometabolic disease. In this review, we discuss the …

Novel risk markers and risk assessments for cardiovascular disease

MR Thomas, GYH Lip - Circulation research, 2017 - Am Heart Assoc
The use of risk markers has transformed cardiovascular medicine, exemplified by the routine
assessment of troponin, for both diagnosis and assessment of prognosis in patients with …

Fibrin clot properties independently predict adverse clinical outcome following acute coronary syndrome: a PLATO substudy

W Sumaya, L Wallentin, SK James… - European heart …, 2018 - academic.oup.com
Aims To determine whether fibrin clot properties are associated with clinical outcomes
following acute coronary syndrome (ACS). Methods and results Plasma samples were …

Platelet-derived microRNAs regulate cardiac remodeling after myocardial ischemia

JP Schütte, MC Manke, K Hemmen, P Münzer… - Circulation …, 2023 - Am Heart Assoc
Background: Platelets can infiltrate ischemic myocardium and are increasingly recognized
as critical regulators of inflammatory processes during myocardial ischemia and reperfusion …

Platelets in cardiac ischaemia/reperfusion injury: a promising therapeutic target

M Ziegler, X Wang, K Peter - Cardiovascular research, 2019 - academic.oup.com
Acute myocardial infarction (AMI) is the single leading cause of mortality and morbidity
worldwide. A key component of AMI therapy is the timely reopening of occluded vessels to …