Developing oncolytic viruses for the treatment of cervical cancer

E Kalafati, E Drakopoulou, NP Anagnou, KI Pappa - Cells, 2023 - mdpi.com
Cervical cancer represents one of the most important malignancies among women
worldwide. Current therapeutic approaches for cervical cancer are reported not only to be …

Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors

P Boscolo-Rizzo, C Furlan, V Lupato, J Polesel… - Clinical …, 2017 - Springer
In the last years, the explosion of high throughput sequencing technologies has enabled
epigenome-wide analyses, allowing a more comprehensive overview of the oropharyngeal …

Regulation of innate immune responses by cell death‐associated caspases during virus infection

Y Fang, K Peng - The FEBS Journal, 2022 - Wiley Online Library
Viruses are obligate intracellular pathogens that rely on cellular machinery for successful
replication and dissemination. The host cells encode a number of different strategies to …

Expression of E8^E2 Is Required for Wart Formation by Mouse Papillomavirus 1 In Vivo

F Stubenrauch, E Straub, K Klein, D Kramer… - Journal of …, 2021 - Am Soc Microbiol
Human papillomavirus (HPV) E1 and E2 proteins activate genome replication. E2 also
modulates viral gene expression and is involved in the segregation of viral genomes. In …

Intratype variants of the E2 protein from human papillomavirus type 18 induce different gene expression profiles associated with apoptosis and cell proliferation

AM Fuentes-González, JO Muñoz-Bello… - Archives of …, 2019 - Springer
Persistent infections with high-risk human papillomaviruses (HR-HPVs) are linked to the
development of cervical cancer due to a deregulation of the productive viral cycle in the host …

Securin overexpression correlates with the activated Rb/E2F1 pathway and histone H3 epigenetic modifications in raw areca nut-induced carcinogenesis in mice

N Boruah, CS Singh, P Swargiary, H Dkhar… - Cancer Cell …, 2022 - Springer
Background Raw areca nut (RAN) consumption induces oral, esophageal and gastric
cancers, which are significantly associated with the overexpression of pituitary tumor …

Focal Adhesion Kinase Binds to the HPV E2 Protein to Regulate Initial Replication after Infection

L Jose, J Gonzalez, E Kessinger, EJ Androphy… - Pathogens, 2023 - mdpi.com
Human papillomaviruses are small DNA tumor viruses that infect cutaneous and mucosal
epithelia. The viral lifecycle is linked to the differentiation status of the epithelium. During …

HPV E2, E5 致癌机制及相关疫苗研究进展

崔湘杰, 史荔, 陶玉芬 - 中华疾病控制杂志, 2024 - zhjbkz.ahmu.edu.cn
宫颈癌是影响女性的常见恶性肿瘤之一, 其中高危型HPV 的持续感染是导致宫颈癌的主要病因.
在宫颈癌的发生发展过程中, 除了HPV E6, E7 与宫颈癌病变有主要的关系外 …

HPV16 E2 variants correlated with radiotherapy treatment and biological significance in cervical cell carcinoma

S Kahla, S Hammami, L Kochbati, MB Chanoufi… - Infection, Genetics and …, 2018 - Elsevier
Specific genetic mutations in human papillomavirus type 16 (HPV16) DNA are considered
important in cervical lesion progression. This study analyzes to what extent radiotherapy …

Research progress in the study of HPV E2, E5 oncogenic mechanism and related vaccine

CUI Xiangjie, SHI Li, TAO Yufen - 中华疾病控制杂志, 2024 - zhjbkz.ahmu.edu.cn
Cervical cancer is one of the common malignancies affecting women worldwide, of which
persistent infection with high-risk human papillomavirus (HPV) is the main cause. In the …