The somatic hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable
(IGHV) gene is a critical biomarker for assessing the prognosis of patients with chronic …

Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

Chronic lymphocytic leukemia (CLL) patients progressed early on ibrutinib often develop
Richter transformation (RT) with a short survival of about 4 months. Preclinical studies …

Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients
with (quasi) identical, stereotyped B-cell receptor (BcR) immunoglobulins. Patients in certain …

The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in
adults, is still largely unknown. The full spectrum of genetic lesions that are present in the …

Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells that is characterized
by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and …

Richter syndrome (RS) is the development of an aggressive lymphoma in patients with
chronic lymphocytic leukemia (CLL). Two pathologic variants of RS are recognized: namely …

Mounting evidence indicates that grouping of chronic lymphocytic leukemia (CLL) into
distinct subsets with stereotyped BCRs is functionally and prognostically relevant. However …

Abstract Analysis of the chronic lymphocytic leukemia (CLL) coding genome has recently
disclosed that the NOTCH1 proto-oncogene is recurrently mutated at CLL presentation …

Richter syndrome (RS) represents the development of diffuse large B-cell lymphoma in the
context of chronic lymphocytic leukemia. The scarcity of biologic information about RS has …