RNA-binding proteins in cancer: old players and new actors
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …
combination of versatility of their RNA-binding domains with structural flexibility enables …
R loops: new modulators of genome dynamics and function
JM Santos-Pereira, A Aguilera - Nature Reviews Genetics, 2015 - nature.com
R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
Ribosomal proteins: functions beyond the ribosome
Although ribosomal proteins are known for playing an essential role in ribosome assembly
and protein translation, their ribosome-independent functions have also been greatly …
and protein translation, their ribosome-independent functions have also been greatly …
SRSF1-regulated alternative splicing in breast cancer
Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression
promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated …
promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated …
[HTML][HTML] SR proteins: binders, regulators, and connectors of RNA
S Jeong - Molecules and cells, 2017 - Elsevier
Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as
constitutive and alternative splicing regulators. As splicing is linked to transcriptional and …
constitutive and alternative splicing regulators. As splicing is linked to transcriptional and …
RNA-binding proteins in cancer: functional and therapeutic perspectives
D Kang, Y Lee, JS Lee - Cancers, 2020 - mdpi.com
Simple Summary RNA-binding proteins (RBPs) play central roles in regulating
posttranscriptional expression of genes. Many of them are known to be deregulated in a …
posttranscriptional expression of genes. Many of them are known to be deregulated in a …
Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer
S Das, AR Krainer - Molecular Cancer Research, 2014 - AACR
Abstract Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR
protein family of splicing regulators. Since its discovery over two decades ago, SRSF1 has …
protein family of splicing regulators. Since its discovery over two decades ago, SRSF1 has …
[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer
H Kędzierska, A Piekiełko-Witkowska - Cancer letters, 2017 - Elsevier
SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the
process of controlled removal of introns and selective joining of exons through which …
process of controlled removal of introns and selective joining of exons through which …