Bioactivity of genistein: A review of in vitro and in vivo studies

AA Ganai, H Farooqi - Biomedicine & pharmacotherapy, 2015 - Elsevier
Genistein is a soy derived isoflavanoid compound with multitude of health benefits. This
compound is found to be a potent agent in both prophylaxis and treatment of cancer and …

Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention

S Ramos - The Journal of nutritional biochemistry, 2007 - Elsevier
Epidemiological studies have described the beneficial effects of dietary polyphenols
(flavonoids) on the reduction of the risk of chronic diseases, including cancer. Moreover, it …

Soy isoflavones and prostate cancer: a review of molecular mechanisms

AM Mahmoud, W Yang, MC Bosland - The Journal of steroid biochemistry …, 2014 - Elsevier
Soy isoflavones are dietary components for which an association has been demonstrated
with reduced risk of prostate cancer (PCa) in Asian populations. However, the exact …

Potential therapeutic applications of some antinutritional plant secondary metabolites

B Singh, TK Bhat, B Singh - Journal of Agricultural and Food …, 2003 - ACS Publications
Plant-based formulations have been used since ancient times as remedial measures
against various human and animal ailments. Over the past 20 years interest in traditional …

Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer

PJ Magee, IR Rowland - British Journal of Nutrition, 2004 - cambridge.org
The incidence of hormone-dependent cancers, such as those of the breast and prostate, is
much lower in Eastern countries such as China and Japan in comparison with the Western …

Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate‐specific antigen

H Ide, S Tokiwa, K Sakamaki, K Nishio, S Isotani… - The …, 2010 - Wiley Online Library
BACKGROUND Sustained chronic inflammation in the prostate promotes prostate
carcinogenesis. Since an elevated level of prostate‐specific antigen (PSA) per se reflects …

Anticancer therapeutic potential of soy isoflavone, genistein

MH Ravindranath, S Muthugounder, N Presser… - Complementary and …, 2004 - Springer
Abstract Genistein (4′ 5, 7-trihydroxyisoflavone) occurs as a glycoside (genistin) in the
plant family Leguminosae, which includes the soybean (Glycine max). A significant …

[HTML][HTML] Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity

AW Nelson, AJ Groen, JL Miller, AY Warren… - Molecular and cellular …, 2017 - Elsevier
Estrogen Receptor-β (ERβ) has been implicated in many cancers. In prostate and breast
cancer its function is controversial, but genetic studies implicate a role in cancer …

Genistein Induces the p21WAF1/CIP1 and p16INK4a Tumor Suppressor Genes in Prostate Cancer Cells by Epigenetic Mechanisms Involving Active Chromatin …

S Majid, N Kikuno, J Nelles, E Noonan, Y Tanaka… - Cancer research, 2008 - AACR
Abstract Genistein (4′, 5, 7-trihydroxyisoflavone) is the most abundant isoflavone found in
the soybean. The effects of genistein on various cancer cell lines have been extensively …

Analytical and compositional aspects of isoflavones in food and their biological effects

A Mortensen, SE Kulling, H Schwartz… - Molecular nutrition & …, 2009 - Wiley Online Library
This paper provides an overview of analytical techniques used to determine isoflavones
(IFs) in foods and biological fluids with main emphasis on sample preparation methods …