Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease

AK Vose, JF Welch, J Nair, EA Dale, EJ Fox… - Experimental …, 2022 - Elsevier
We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

The impact of high-intensity interval training on brain derived neurotrophic factor in brain: a mini-review

A Jiménez-Maldonado, I Rentería… - Frontiers in …, 2018 - frontiersin.org
The brain-derived neurotrophic factor (BDNF) is a protein mainly synthetized in the neurons.
Early evidence showed that BDNF participates in cognitive processes as measured at the …

Role of DNA methyl-CpG-binding protein MeCP2 in Rett syndrome pathobiology and mechanism of disease

S Pejhan, M Rastegar - Biomolecules, 2021 - mdpi.com
Rett Syndrome (RTT) is a severe, rare, and progressive developmental disorder with
patients displaying neurological regression and autism spectrum features. The affected …

High-intensity intermittent training enhances spatial memory and hippocampal neurogenesis associated with BDNF signaling in rats

M Okamoto, D Mizuuchi, K Omura, M Lee… - Cerebral …, 2021 - academic.oup.com
High-intensity intermittent (or interval) training (HIIT) has started to gain popularity as a time-
effective approach to providing beneficial effects to the brain and to peripheral organs …

Ischaemic and hypoxic conditioning: potential for protection of vital organs

JD Sprick, RT Mallet, K Przyklenk… - Experimental …, 2019 - Wiley Online Library
New Findings What is the topic of this review? Remote ischaemic preconditioning (RIPC)
and hypoxic preconditioning as novel therapeutic approaches for cardiac and …

Acute intermittent hypoxia enhances corticospinal synaptic plasticity in humans

L Christiansen, MA Urbin, GS Mitchell, MA Perez - Elife, 2018 - elifesciences.org
Acute intermittent hypoxia (AIH) enhances voluntary motor output in humans with central
nervous system damage. The neural mechanisms contributing to these beneficial effects are …

Respiratory neuroplasticity: Mechanisms and translational implications of phrenic motor plasticity

GS Mitchell, TL Baker - Handbook of Clinical Neurology, 2022 - Elsevier
Widespread appreciation that neuroplasticity is an essential feature of the neural system
controlling breathing has emerged only in recent years. In this chapter, we focus on …

The Hypoxia Response Pathway: A Potential Intervention Target in Parkinson's Disease?

JM Janssen Daalen, WJH Koopman… - Movement …, 2024 - Wiley Online Library
Parkinson's disease (PD) is a progressive neurodegenerative disorder for which only
symptomatic treatments are available. Both preclinical and clinical studies suggest that …

Respiratory neuroplasticity–Overview, significance and future directions

DD Fuller, GS Mitchell - Experimental neurology, 2017 - Elsevier
Neuroplasticity is an important property of the neural system controlling breathing. However,
our appreciation for its importance is still relatively new, and we have much to learn …

Acute intermittent hypoxia boosts spinal plasticity in humans with tetraplegia

L Christiansen, B Chen, Y Lei, MA Urbin… - Experimental …, 2021 - Elsevier
Paired corticospinal-motoneuronal stimulation (PCMS) elicits spinal synaptic plasticity in
humans with chronic incomplete cervical spinal cord injury (SCI). Here, we examined …