Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …

Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …

PubChem's BioAssay database (https://pubchem. ncbi. nlm. nih. gov) has served as a public
repository for small-molecule and RNAi screening data since 2004 providing open access of …

Future directions in the treatment of osteosarcoma : Current Opinion in Pediatrics Future
directions in the treatment of osteosarcoma : Current Opinion in Pediatrics Log in or Register …

Over the past decade, rapid advances in genomics, proteomics and functional genomics
technologies that enable in-depth interrogation of cancer genomes and proteomes and high …

High-grade osteosarcomas are the most common primary malignant tumors of bone. With
complete surgical resection and multi-agent chemotherapy up to 70% of patients with high …

Osteosarcoma is the most common primary malignant bone tumor, predominantly occurring
in children and adolescents. Despite treated with surgery and neoadjuvant chemotherapy …

Osteosarcoma as an aggressive malignant neoplasm is commonly treated by surgical
resection, chemotherapy, and radiotherapy, but surgery induces bone defects and …

Patients who are diagnosed with osteosarcoma (OS) today receive the same therapy that
patients have received over the last 4 decades. Extensive efforts to identify more effective or …

Sonosensitizers play crucial roles in the controlled production of reactive oxygen species
(ROS) under ultrasound (US) irradiation with high tissue-penetration depth for noninvasive …