Inner ear drug delivery for sensorineural hearing loss: current challenges and opportunities

SS Liu, R Yang - Frontiers in Neuroscience, 2022 - frontiersin.org
Most therapies for treating sensorineural hearing loss are challenged by the delivery across
multiple tissue barriers to the hard-to-access anatomical location of the inner ear. In this …

The benefits of preserving residual hearing following cochlear implantation: a systematic review

S Schaefer, M Sahwan, A Metryka, K Kluk… - International journal of …, 2021 - Taylor & Francis
Objective Systematically review the current literature for evidence on the “real-life” benefits
of hearing preservation cochlear implantation (HPCI) for children and adults. Design …

Electro-vibrational stimulation results in improved speech perception in noise for cochlear implant users with bilateral residual hearing

A Geerardyn, K De Voecht, J Wouters, N Verhaert - Scientific Reports, 2023 - nature.com
A cochlear implant is a neuroprosthetic device that can restore speech perception for people
with severe to profound hearing loss. Because of recent evolutions, a growing number of …

Three-dimensional quantification of fibrosis and ossification after cochlear implantation via virtual re-sectioning: Potential implications for residual hearing

A Geerardyn, MY Zhu, P Wu, JT O'Malley, JB Nadol Jr… - Hearing research, 2023 - Elsevier
Hearing preservation may be achieved initially in the majority of patients after cochlear
implantation, however, a significant proportion of these patients experience delayed hearing …

[HTML][HTML] Gene therapy with a synthetic adeno-associated viral vector improves audiovestibular phenotypes in Pjvk-mutant mice

YC Lu, YH Tsai, YH Chan, CJ Hu, CY Huang, R Xiao… - JCI insight, 2022 - ncbi.nlm.nih.gov
Recessive PJVK mutations that cause a deficiency of pejvakin, a protein expressed in both
sensory hair cells and first-order neurons of the inner ear, are an important cause of …

Min-max similarity: A contrastive semi-supervised deep learning network for surgical tools segmentation

A Lou, K Tawfik, X Yao, Z Liu… - IEEE Transactions on …, 2023 - ieeexplore.ieee.org
A common problem with segmentation of medical images using neural networks is the
difficulty to obtain a significant number of pixel-level annotated data for training. To address …

The effect of the surgical approach and cochlear implant electrode on the structural integrity of the cochlea in human temporal bones

S Jwair, H Versnel, RJ Stokroos, HGXM Thomeer - Scientific Reports, 2022 - nature.com
Cochlear implants (CI) restore hearing of severely hearing-impaired patients. Although this
auditory prosthesis is widely considered to be very successful, structural cochlear trauma …

Human histology after structure preservation cochlear implantation via round window insertion

A Geerardyn, MY Zhu, T Klabbers, W Huinck… - The …, 2024 - Wiley Online Library
Objectives Current surgical techniques aim to preserve intracochlear structures during
cochlear implant (CI) insertion to maintain residual cochlear function. The optimal technique …

Is characteristic frequency limiting real-time electrocochleography during cochlear implantation?

A Walia, MA Shew, SM Lefler, D Kallogjeri… - Frontiers in …, 2022 - frontiersin.org
Objectives Electrocochleography (ECochG) recordings during cochlear implantation have
shown promise in estimating the impact on residual hearing. The purpose of the study was …

Current concepts and future trends in increasing the benefits of cochlear implantation: a narrative review

CM Blebea, LP Ujvary, V Necula, MG Dindelegan… - Medicina, 2022 - mdpi.com
Hearing loss is the most common neurosensory disorder, and with the constant increase in
etiological factors, combined with early detection protocols, numbers will continue to rise …