The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Tumor relapse and metastasis are the primary causes of poor survival rates in patients with
advanced cancer despite successful resection or chemotherapeutic treatment. A primary …

Background: Tumor models are critical for our understanding of cancer and the development
of cancer therapeutics. The 4T1 murine mammary cancer cell line is one of the most widely …

Background—We previously reported high-throughput RNA sequencing analyses that
identified heightened expression of the chromatin architectural factor High Mobility Group AT …

Endothelial-to-mesenchymal transition (EndMT) is a process that encompasses extensive
transcriptional reprogramming of activated endothelial cells leading to a shift toward …

Adipose tissue is a reservoir of Mesenchymal Stem Cells (Adipose-derived Mesenchymal
Stem Cells, ASCs), endowed with regenerative properties. Fat graft was proposed for breast …

Background The progression of cancer through stages that guide a benign hyperplastic
epithelial tissue towards a fully malignant and metastatic carcinoma, is driven by genetic and …

Cancer cells frequently exploit the IGF signaling, a fundamental pathway mediating
development, cell growth, and survival. As a consequence, several components of the IGF …

The high mobility group A1 (HMGA1) gene plays an important role in numerous malignant
cancers. HMGA1 is an oncofoetal gene, and we have a certain understanding of the …

HMGA (high mobility group A)(HMGA1 and HMGA2) are small non-histone proteins that can
bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors …