Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the
past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein …

Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …

Recent studies have begun to reveal critical roles for the brain's professional phagocytes,
microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin …

In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …

Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …

We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …