Podocytopathies

JB Kopp, HJ Anders, K Susztak, MA Podestà… - Nature Reviews …, 2020 - nature.com
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

The glomerular filtration barrier: a structural target for novel kidney therapies

IS Daehn, JS Duffield - Nature Reviews Drug Discovery, 2021 - nature.com
Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Biochemistry of mitochondrial coenzyme Q biosynthesis

JA Stefely, DJ Pagliarini - Trends in biochemical sciences, 2017 - cell.com
Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid produced across all domains of life
that functions in electron transport and oxidative phosphorylation and whose deficiency …

Mitochondrial dysfunction in inherited renal disease and acute kidney injury

F Emma, G Montini, SM Parikh, L Salviati - Nature Reviews Nephrology, 2016 - nature.com
Mitochondria are increasingly recognized as key players in genetic and acquired renal
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …

[HTML][HTML] Coenzyme Q biosynthesis in health and disease

MJ Acosta, LV Fonseca, MA Desbats, C Cerqua… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Coenzyme Q (CoQ, or ubiquinone) is a remarkable lipid that plays an essential role in
mitochondria as an electron shuttle between complexes I and II of the respiratory chain, and …

Understanding ubiquinone

Y Wang, S Hekimi - Trends in cell biology, 2016 - cell.com
Ubiquinone (UQ; also known as coenzyme Q; CoQ) is a mobile component of the
mitochondrial electron transport chain, where it acts as a pro-oxidant in its ubisemiquinone …

Molecular mechanisms in early diabetic kidney disease: glomerular endothelial cell dysfunction

E Lassén, IS Daehn - International journal of molecular sciences, 2020 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with
prevalence increasing at an alarming rate worldwide and today, there are no known cures …

Genetic bases and clinical manifestations of coenzyme Q10 (CoQ10) deficiency

MA Desbats, G Lunardi, M Doimo, E Trevisson… - Journal of inherited …, 2015 - Springer
Coenzyme Q 10 is a remarkable lipid involved in many cellular processes such as energy
production through the mitochondrial respiratory chain (RC), beta-oxidation of fatty acids …

Coenzyme Q10 deficiencies: pathways in yeast and humans

AM Awad, MC Bradley… - Essays in …, 2018 - portlandpress.com
Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial
respiratory electron transport and serves as an important antioxidant. In human and yeast …

[PDF][PDF] An overview of therapeutic effects of vanillic acid

N Sharma, N Tiwari, M Vyas, N Khurana… - Plant Arch, 2020 - academia.edu
Vanillic acid (VA) is a derivative of benzoic acid which is used as a flavouring agent,
preservative, and food additive in the food industry. VA is phenolic molecule that is oxidized …