Podocytopathies
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
The glomerular filtration barrier: a structural target for novel kidney therapies
IS Daehn, JS Duffield - Nature Reviews Drug Discovery, 2021 - nature.com
Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …
Biochemistry of mitochondrial coenzyme Q biosynthesis
JA Stefely, DJ Pagliarini - Trends in biochemical sciences, 2017 - cell.com
Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid produced across all domains of life
that functions in electron transport and oxidative phosphorylation and whose deficiency …
that functions in electron transport and oxidative phosphorylation and whose deficiency …
Mitochondrial dysfunction in inherited renal disease and acute kidney injury
Mitochondria are increasingly recognized as key players in genetic and acquired renal
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …
[HTML][HTML] Coenzyme Q biosynthesis in health and disease
MJ Acosta, LV Fonseca, MA Desbats, C Cerqua… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Coenzyme Q (CoQ, or ubiquinone) is a remarkable lipid that plays an essential role in
mitochondria as an electron shuttle between complexes I and II of the respiratory chain, and …
mitochondria as an electron shuttle between complexes I and II of the respiratory chain, and …
Understanding ubiquinone
Y Wang, S Hekimi - Trends in cell biology, 2016 - cell.com
Ubiquinone (UQ; also known as coenzyme Q; CoQ) is a mobile component of the
mitochondrial electron transport chain, where it acts as a pro-oxidant in its ubisemiquinone …
mitochondrial electron transport chain, where it acts as a pro-oxidant in its ubisemiquinone …
Molecular mechanisms in early diabetic kidney disease: glomerular endothelial cell dysfunction
E Lassén, IS Daehn - International journal of molecular sciences, 2020 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with
prevalence increasing at an alarming rate worldwide and today, there are no known cures …
prevalence increasing at an alarming rate worldwide and today, there are no known cures …
Genetic bases and clinical manifestations of coenzyme Q10 (CoQ10) deficiency
MA Desbats, G Lunardi, M Doimo, E Trevisson… - Journal of inherited …, 2015 - Springer
Coenzyme Q 10 is a remarkable lipid involved in many cellular processes such as energy
production through the mitochondrial respiratory chain (RC), beta-oxidation of fatty acids …
production through the mitochondrial respiratory chain (RC), beta-oxidation of fatty acids …
Coenzyme Q10 deficiencies: pathways in yeast and humans
AM Awad, MC Bradley… - Essays in …, 2018 - portlandpress.com
Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial
respiratory electron transport and serves as an important antioxidant. In human and yeast …
respiratory electron transport and serves as an important antioxidant. In human and yeast …
[PDF][PDF] An overview of therapeutic effects of vanillic acid
Vanillic acid (VA) is a derivative of benzoic acid which is used as a flavouring agent,
preservative, and food additive in the food industry. VA is phenolic molecule that is oxidized …
preservative, and food additive in the food industry. VA is phenolic molecule that is oxidized …