Current recommendations and recent progress in endometrial cancer

RA Brooks, GF Fleming, RR Lastra… - CA: a cancer journal …, 2019 - Wiley Online Library
Endometrial cancer is the most common gynecologic cancer in the United States, and its
incidence is rising. Although there have been significant recent advances in our …

Clinical actionability of molecular targets in endometrial cancer

ME Urick, DW Bell - Nature Reviews Cancer, 2019 - nature.com
Abstract Endometrial cancer accounts for~ 76,000 deaths among women each year
worldwide. Disease mortality and the increasing number of new diagnoses make …

[HTML][HTML] Integrated analysis of TP53 gene and pathway alterations in the cancer genome atlas

LA Donehower, T Soussi, A Korkut, Y Liu, A Schultz… - Cell reports, 2019 - cell.com
The TP53 tumor suppressor gene is frequently mutated in human cancers. An analysis of
five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer …

Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening

M Boretto, N Maenhoudt, X Luo, A Hennes… - Nature cell …, 2019 - nature.com
Endometrial disorders represent a major gynaecological burden. Current research models
fail to recapitulate the nature and heterogeneity of these diseases, thereby hampering …

[HTML][HTML] A clinically applicable molecular-based classification for endometrial cancers

A Talhouk, MK McConechy, S Leung… - British journal of …, 2015 - nature.com
Background: Classification of endometrial carcinomas (ECs) by morphologic features is
inconsistent, and yields limited prognostic and predictive information. A new system for …

[HTML][HTML] Integrated genomic characterization of endometrial carcinoma

DA Levine… - Nature, 2013 - nature.com
We performed an integrated genomic, transcriptomic and proteomic characterization of 373
endometrial carcinomas using array-and sequencing-based technologies. Uterine serous …

New concepts for an old problem: the diagnosis of endometrial hyperplasia

PA Sanderson, HOD Critchley… - Human reproduction …, 2017 - academic.oup.com
BACKGROUND Endometrial hyperplasia (EH) is a uterine pathology representing a
spectrum of morphological endometrial alterations. It is predominantly characterized by an …

[HTML][HTML] Integrated molecular characterization of uterine carcinosarcoma

AD Cherniack, H Shen, V Walter, C Stewart, BA Murray… - Cancer cell, 2017 - cell.com
We performed genomic, epigenomic, transcriptomic, and proteomic characterizations of
uterine carcinosarcomas (UCSs). Cohort samples had extensive copy-number alterations …

Classification of endometrial carcinoma: more than two types

R Murali, RA Soslow, B Weigelt - The Lancet Oncology, 2014 - thelancet.com
Endometrial cancer is the most common gynaecological malignancy in Europe and North
America. Traditional classification of endometrial carcinoma is based either on clinical and …

Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis

J Huvila, J Pors, EF Thompson… - The Journal of …, 2021 - Wiley Online Library
Endometrial carcinoma (EC) is classified into a wide range of morphological variants; this list
has expanded over the past decade with the inclusion of mesonephric‐like and …