Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics
M Alda - Molecular psychiatry, 2015 - nature.com
After decades of research, the mechanism of action of lithium in preventing recurrences of
bipolar disorder remains only partially understood. Lithium research is complicated by the …
bipolar disorder remains only partially understood. Lithium research is complicated by the …
Encore: Behavioural animal models of stress, depression and mood disorders
A Petković, D Chaudhury - Frontiers in behavioral neuroscience, 2022 - frontiersin.org
Animal studies over the past two decades have led to extensive advances in our
understanding of pathogenesis of depressive and mood disorders. Among these, rodent …
understanding of pathogenesis of depressive and mood disorders. Among these, rodent …
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study
Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However …
variable. Previous studies have suggested that lithium response is a heritable trait. However …
The emergent course of bipolar disorder: observations over two decades from the Canadian high-risk offspring cohort
Objective: The authors sought to describe the emergent course of bipolar disorder in
offspring of affected parents subgrouped by parental response to lithium prophylaxis …
offspring of affected parents subgrouped by parental response to lithium prophylaxis …
Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium
Bipolar disorder (BD) is a progressive psychiatric disorder with more than 3% prevalence
worldwide. Affected individuals experience recurrent episodes of depression and mania …
worldwide. Affected individuals experience recurrent episodes of depression and mania …
[HTML][HTML] Animal models in psychiatric research: The RDoC system as a new framework for endophenotype-oriented translational neuroscience
E Anderzhanova, T Kirmeier, CT Wotjak - Neurobiology of stress, 2017 - Elsevier
Abstract The recently proposed Research Domain Criteria (RDoC) system defines
psychopathologies as phenomena of multilevel neurobiological existence and assigns them …
psychopathologies as phenomena of multilevel neurobiological existence and assigns them …
Insulin resistance and outcome in bipolar disorder
BackgroundLittle is known about the impact of insulin resistance on bipolar disorder. AimsTo
examine the relationships between insulin resistance, type 2 diabetes and clinical course …
examine the relationships between insulin resistance, type 2 diabetes and clinical course …
Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
Lithium is the gold standard therapy for Bipolar Disorder (BD) but its effectiveness differs
widely between individuals. The molecular mechanisms underlying treatment response …
widely between individuals. The molecular mechanisms underlying treatment response …
Genetic overlap between attention-deficit/hyperactivity disorder and bipolar disorder: evidence from genome-wide association study meta-analysis
Background Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BPD) are
frequently co-occurring and highly heritable mental health conditions. We hypothesized that …
frequently co-occurring and highly heritable mental health conditions. We hypothesized that …
Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder
AT Amare, A Thalamuthu, KO Schubert… - Molecular …, 2023 - nature.com
Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and
disabling mental health disorder that affects about 1% of the population worldwide …
disabling mental health disorder that affects about 1% of the population worldwide …