Phosphatase and tensin homolog (PTEN) is a classical tumor suppressor that antagonizes
phosphatidylinositol 3-phosphate kinase (PI3K)/AKT signaling. Although there is a strong …

Autism spectrum disorder (ASD) comprises a group of multifactorial neurodevelopmental
disorders primarily characterized by deficits in social interaction and repetitive behavior …

Abstract Background Neurodevelopmental disorders (NDDs), including autism spectrum
disorder (ASD) and intellectual disability (ID), are common diagnoses with highly …

Intellectual disability (ID) and autism spectrum disorder (ASD) are neurodevelopmental
disorders that have become a primary clinical and social concern, with a prevalence of 2 …

Metabolites of the Amyloid-β precursor protein (APP) proteolysis may underlie brain
overgrowth in Autism Spectrum Disorder (ASD). We have found elevated APP metabolites …

The mechanistic target of rapamycin (mTOR) pathway is a signaling system integral to
neural growth and migration. In both patients and rodent models, mutations to the …

A subset of individuals with autism spectrum disorder (ASD) and macrocephaly carry
mutations in the gene PTEN. Animal models, particularly mice, have been helpful in …

Adult neurogenesis is a persistent phenomenon in mammals that occurs in select brain
structures in both healthy and diseased brains. The tumor suppressor gene, phosphatase …

Down syndrome (DS) is the most example of aneuploidy, resulting from an additional copy
of all or part of chromosome 21. Competing endogenous RNAs (ceRNAs) play important …

The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene is a critical
tumor suppressor that plays an essential role in the development and functionality of the …